Dear Experimenter,
Here’s a fresh set of answers to frequently asked questions (FAQs) about design of experiments (DOE); plus timely alerts for events, publications and software updates. Check it out!
- Mark
StatsMadeEasy Blog
(My wry look at all things statistical and/or scientific with an engineering perspective) Also, see the Stat-Ease blog here for tips on making DOE easy. For example, a recent posting provides “Experimental Design in Chemistry: A Review of Pitfalls” contributed by our friend James Cawse. Check it out!
Topics in the body text of this DOE FAQ Alert are headlined below (the “Expert” ones, if any, delve into statistical details):
  1. Software Alert: Version 12.0.4 of Design‑Expert® software released
  2. Webinar alert: DOE Made Easy with version 12 of Design‑Expert® software (DX12)
  3. Event Alert: 8th European DOE Meeting coming in June 2020—save the date and consider answering the 1st call for papers
  4. FAQ: What to do with a “way off” run on the normal plot of residuals
  5. Workshop alert: Tool up in 2020 for doing DOE by scheduling a Stat‑Ease class—check out the upcoming dates and locations
P.S. Quote for the month: Another gem from George Box.
(Page down to the end of this e-zine to enjoy the actual quote.)
Software Alert: Version 12.0.4 of DesignExpert software released
Current Design-Expert v12 (DX12) users will do well by updating to 12.0.4 via Help from within your installed program. View the changelog for details on the changes—mainly maintenance items. If you want to receive notice when an update becomes available, go to Edit on the main menu of your program, select Preferences and, within the default General tab, turn on (if not already on by default) the “Check for updates on program start” option. (This alert feature is not available in network versions.)

If you remain mired in an obsolete version or are not yet a user of Design‑Expert, click here for the highlights on what’s new in DX12 (plus more details on added features). Then, assuming you like what you see, follow the FREE TRIAL link for a 30‑day tryout or buy it directly, taking advantage of upgrade pricing if eligible.

You will do well by gaining the leading edge on DOE capability by upgrading your software to DX12.0.4!
Webinar alert: DOE Made Easy with version 12 of DesignExpert® software (DX12)
In this 1 hour, beginner’s level webinar, I will detail what DOE can do for you when catalyzed with DX12’s world-class statistical tools. Learn about factorial design, the core tool for DOE, followed by a peek at response surface methods (RSM) for process optimization and last, but not least, a look into mixture design for optimal formulation. The dates and times (Central USA) will be:
  • Monday, January 27, 7:30 pm for Australia, NZ and eastern Asia (others welcome!)
  • Wednesday, January 29, 6:30 am for Europe, Africa, India, the Middle East and western Asia (others welcome!)
  • Thursday, January 30, 12:30 pm for the Americas and Caribbean (others welcome!)
To register for this free, live webinar, go to
Event Alert: 8th European DOE Meeting coming to Groningen, Netherlands in June 2020—save the date and consider answering the call for speakers
To learn and, perhaps speak on, how to “Make the Most from Every Experiment” reserve June 18-19 on your calendar for the 8th European DOE Meeting in Groningen, Netherlands. Stat‑Ease reseller Science Plus Group reserved the exclusive Het Kasteel (The Castle) in the City Center for our gathering of Design‑Expert software users and experts in DOE. Come for the meetings and leave time before and/or after to tour this historic European region.

Submit your abstracts for consideration of a speaking slot by emailing it to We hope to see you in the Netherlands next summer.
FAQ: What to do with a “way off” run on the normal plot of residuals
Original question from a Technical Service Manager:
“I remember from class that there was something to do when we have a way off residual. But I can’t remember what.”

Answer from Stat-Ease Consultant Martin Bezener:
“First check for a mistake in the data entry, for example, you mistyped ‘68’ for an actual result of 86. Then, assuming you encountered no obvious problems during the run, such as a breakdown in the equipment, consider re-doing the run, if it can be done quickly and at little cost, to confirm it's actually an outlier. Next, I suggest looking at the Box-Cox plot in the Diagnostics to see if a transform can help. If none of the above help, try ignoring the run.”

Follow up from the Technical Service Manager:
“I double checked the data and in fact an erroneous number was entered.”

(Learn more about diagnostic plots by attending the three-day computer-intensive workshop on Modern DOE for Process Optimization. Click the link for a description of this class and registration details.)
Workshop alert: Tool up in 2020 for doing DOE by scheduling a Stat-Ease class—check out the upcoming dates and locations
You can do no better for quickly advancing your DOE skills than attending a Stat‑Ease workshop. Our expert instructors provide you with a lively and extremely informative series of lectures interspersed by valuable hands-on exercises. Enroll at least 6 weeks prior to the date so your place can be assured—plus get a 10% “early-bird” discount.
Experiment Design Made Easy (EDME)
     - January 28-29, San Diego, CA
     - March 9–10, Austin, TX*
     * Paired with Camo Analytics March 11-13 class on
       Multivariate Data Analysis – Level 1.

Modern DOE for Process Optimization (MDOE)
     - January 28-30, San Diego, CA

Mixture Design for Optimal Formulations (MIXC)
     - April 1-2, Cleveland, OH
See this web page for complete schedule and site information on all Stat‑Ease workshops open to the public. To enroll, scroll down to the workshop of your choice and click on it, or email our Lead Client Specialist Rachel Poleke at If spots remain available, bring along several colleagues and take advantage of quantity discounts in tuition. Or, consider bringing in an expert from Stat-Ease to teach a private class at your site.*

*Once you achieve a critical mass of about 6 students, it becomes very economical to sponsor an on-site workshop, which is most convenient and effective for your staff. For a quote, email
I hope you learned something from this issue. Address your general questions and comments to me at:



Mark J. Anderson, PE, CQE
Principal, Stat-Ease, Inc.

"Make the most from every experiment!"

“Good science is a form of wit, of seeing the joke that nature is playing on us.”
  - From Preface to An Accidental Statistician: The Life and Memories of George E. P. Box, page xix, 2013, John Wiley & Sons.
Trademarks: Stat-Ease, Design-Expert and Statistics Made Easy are registered trademarks of Stat-Ease, Inc.

Acknowledgements to contributors:
  • Students of Stat-Ease training and users of Stat-Ease software
  • Stat-Ease consultants: Pat Whitcomb, Martin Bezener, and Shari Kraber
  • Stat-Ease programmers: Hank Anderson, Joe Carriere, and Mike Brownson
  • Stat-Ease business staff—Cathy Hickman, Greg Campbell, and Rachel Poleke—who provide such supreme support!
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