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Vol. 25, No. 4 - July/August 2025

IN THIS ISSUE: model hierarchy, biotech/pharma workshop, and more

FAQ

Why include insignificant terms in a model?

Original question from a Principal Scientist:


“Why does Stat-Ease software include factor B in my model when only A and AB are significant at p<0.05?”


Answer :
Terms such as factor B, though insignificant, must be included to maintain hierarchy and thus avoid creating a predictive model that does not convert properly from the coded to actual equation. It’s a math thing.* Without the insignificant terms present as placeholders, some cross products from the conversion fall away, creating what’s called an “ill-formulated polynomial model” that is not invariant to coding. “Consequently, measures of goodness of fit [such as R^squared!] of a not-well-formulated model may be affected by coding transformations.”*


If that is not scary enough, consider the implications of saying that a factor like B is not significant when it really creates an impact in combination with factor A. That can be very misleading. From my perspective as a process development and certified quality engineer who many-a-time defended results from designed experiments, this may be a most compelling reason to include model terms needed to maintain hierarchy.


While being trained by George Box, I heard him say that “if you are going to do something, you may as well do it right.” So, my advice when the software warns you about a non-hierarchical model and asks if you should correct it, is just say “Yes.”


*See our program-Help advanced topic detailing how to convert a coded response surface model to actual.

**“A Property of Well-Formulated Polynomial Regression Models,” Julio L. Peixoto, The American Statistician, Vol. 44, No. 1 (Feb, 1990), pp. 26-30.


PS: My consulting colleague Joe provides this helpful detail: “To maintain hierarchy, our software starts by testing highest order effects and then proceeds to the lower order ones. That is, it goes from bottom to top on the ANOVA table. If a higher order term is significant, the software (unless you say ‘No’ to hierarchy, which I do not recommend) retains any lower order terms that compose it.


(Learn more about predictive modeling by enrolling in the next Modern DOE for Process Optimization public workshop.)

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INFO

The July issue of The Journal of Plastic Film and Sheeting provides tips by me for "Applying covariate analysis to refine models from process studies."


See our latest publication roundup, featuring application of Stat-Ease software for exceptionally successful experiments.

BLOGS


StatsMadeEasy

My wry look at all things statistical and/or scientific with an engineering perspective.


Stat-Ease Blog

Great tips from the Stat-Ease team for making DOE easy, for example, this recent post by me on “"Salvaging a designed experiment via covariate analysis.”

Feel free to get back to me via [email protected] with further questions or comments: I would really appreciate hearing from you!

All the best,

Mark J. Anderson, PE, CQE, MBA
Engineering Consultant, Stat-Ease, Inc.
www.linkedin.com/in/markstat/

QUOTE OF THE DAY

“No experiment is a failure; it can always be used as a bad example.”

–Paul Dickson (I thank Morten Bormann Nielsen for this quote, which he related in his Summit talk on “The one that got away – Experiments avoided through DOE,” which can be seen here on the Stat-Ease YouTube channel.)


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